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MEDRU

MEDRU

Pr. Abdoulaye DJIMDE

Pr. Abdoulaye DJIMDE

Lead

Laboratories and their role within the parent organization

The MEDRU laboratories are part of the MRTC/DEAP and have been in operation since 2001.


A thorough understanding of our laboratory’s objectives for our employees is essential. We continuously train, update and engage employees based on our mission and the services we provide to our partners. We assess the capabilities and expertise of our human resources (HR) and employees in light of our missions and the objectives and requirements of our partners.

At each specific activity, appropriate persons are designated to carry out this task. Designated individuals will manage reagent, consumable, inventory and order requirements. These individuals are responsible for sample processing, collection, data analysis and the development of the study report. Data management includes protocol approval, record keeping and electronic media to ensure data accuracy and avoid bias. The data is saved in the PCR laboratory and also saved on the DELGEME server by our IT manager. Access to data is limited to employees and partners if necessary. Access to samples and data is restricted to authorized personnel (high confidentiality, password protection, lock-in of archives, restriction of access to data).

Access to samples and data is restricted to authorized personnel (high confidentiality, password protection, lock-in of archives, restriction of access to data). The MEDRU/MRTC/DEAP Laboratory Manager works with the designated individuals to regularly evaluate our operation and take corrective action to ensure good performance at each step of the procedures.

  1. The missions of our laboratories are:
    • Basic and applied research (The main laboratory MEDRU/MRTC/DEAP
      • Point-G and the laboratory of Sotuba)

      • Drug discovery

      • Drug resistance

      • Cell Biology

      • Genomics and Bioinformatics

      • Pharmacology [PD, PK, PG]

      • Nutrition

      • Entomology
    • Clinical research (MEDRU/MRTC/DEAP-Sotuba, Bougoula, Kolle, Djoliba, Faladie)

      • Clinical Trials
      • Field observation studies
      • Design of studies
      • 
Internal Monitoring
    • Partner and Client Services (MEDRU/MRTC/DEAP-Point-G and Sotuba Laboratory)

      • Sample Management

      • Analysis of Samples

      • Report writing

    Quality Assurance, Health and Safety (All laboratories MEDRU/MRTC/DEAP)


    • Data Management and Sharing (The MEDRU/MRTC/DEAP-Point-G main laboratory and the Sotuba laboratory)
    • Scientific Commission (All MEDRU/MRTC/DEAP laboratories)

      • Search for funding opportunities

      • Scientific Writing and Valorisation of Research

      • Training

    The MEDRU laboratories carry out their activities on the premises of the MRTC/DEAP and on different study sites throughout Mali. MEDRU laboratories provide services in support of the National Malaria Control Programme (PNLP) and research projects conducted by other research structures according to their requests. They regularly analyze biological samples from clinical trials in other national and international structures.

  2. Laboratory Activities and Services

    To achieve its objectives, MEDRU laboratories have the following platforms:

    • Clinical Trials: (The MEDRU/MRTC/DEAP- sites of Bougoula, Djoliba, Faladie, Kolle, Sotuba) Classical Polymerase Chain Reaction (PCR) and quantitative PCR for molecular diagnosis (The main laboratory MEDRU/MRTC/DEAP-Point-G and the laboratory of Sotuba)
    • Advanced biochemistry and hematology machines are used to measure the following parameters: ALAT, ASAT, Glucose, Total and Direct bilirubins, Creatinine, ions (potassium, chlorine, calcium, magnesium), blood count (The MEDRU/MRTC/DEAP laboratories in Bougoula, Kolle and Sotuba)
    • Cell cultures are conducted to understand the in vitro/ex vivo resistance mechanism and for the screening of new drugs (The main laboratory MEDRU/MRTC/DEAP-Point-G). Insectarium (Captures of vectors and experimental infestations are carried out to evaluate the parameters related to transmission in collaboration with our entomologist colleagues). (The main laboratory MEDRU/MRTC/DEAP- Point-G and the laboratory of Bougoula)
    • High Performance Liquid Chromatography (HPLC) machines are used for the dosing of drugs and their metabolites (The main laboratory MEDRU/MRTC/DEAP- Point-G). Impedance meter and FTIR for nutritional assessment (The main laboratory MEDRU/MRTC/DEAP- Point-G)
    • A platform for high-throughput sequencing (The main laboratory MEDRU/MRTC/DEAP- Point-G)

Organizational chart